Lab-based course on design and synthetic preparation of drugs and extraction procedures.
THEORETICAL LESSONS
General aspects of the research and development of natural and synthetic biologically active compounds. Rational drug design: SBBD and LBDD.
Retrosynthetic analysis. Multistep synthesis and multicomponent reactions.
Bibliographic search.
Synthetic laboratory techniques: elaboration of a synthetic plan; assembling, conducting and monitoring reactions; work-up of reaction mixtures; isolation, purification and identification of reaction products.
Extraction techniques.
Guidelines for keeping a Laboratory Record and writing laboratory reports.
LABORATORY PRACTICE
General instructions for safe working in chemical laboratories.
Synthesis and extraction of compounds of pharmaceutical interest: isolation, purification and full characterization.
Case-studies: design and synthesis of biologically active compounds.
Separation of compounds in mixture by extration procedures.