EPIGENETICS AND GENE REGULATION

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2016/2017

Type of Course:

Characterising

Optional/Mandatory:

Compulsory

Degree:

Master's Degree Programme in EXPERIMENTAL AND APPLIED BIOLOGY

Disciplinary Sector:

MOLECULAR BIOLOGY

Language:

Italian

Credits:

Programme Year:

Professor and Collaborators:

CROSIO Claudia

Hours of classroom activity:

Prerequisites:

Structure of macromolecules. Weak and strong bonds in macromolecular structures. Principles of genetics: Mendel's law of heredity. Principles of Biochemistry.

AF code:

A000605

Assessment Methods

Verification of learning:

Final oral exam

Teaching period

First semester

Objectives

This course will cover the principles of epigenetic control of gene expression, how epigenetic control contributes to cellular differentiation and development, and how it goes wrong in disease.

Contents

GENE EXPRESSION ANALISYS: RNA interference, gene-targeting, genome-editing nucleas
EPIGENETIC CONTROL OF GENE EXPRESSION
Introduction to epigenetics
Epigenetic modifications and their function in regulating gene expression and chromosome structure: DNA methylation and covalent histone modifications.
Epigenetic regulation and deregulation in cell cycle and cancer
Transcriptional and epigenetic mechanisms of addiction
Epigentic and cell fate determination and stem cells biology
POST-TRANSCRIPTIONAL REGULATION AND THERAPEUTIC RNA
post-transcriptional control: alternative splicing and editing
Therapeutic RNA
LABORATORY ACTIVITIES: ChIP

Recommended Bibliography

1) L. Armstrong "Epigenetics" Garland Science
2) Epigenetics © 2006 Cold Spring Harbor Laboratory Press
3) Molecular Biology of the Gene- Watson et al.,
4) Extra reading material - a list of review articles

The slides and other materials used for lectures is made available to the students on the online moodle platform.

Methods of Provision

Conventional

Teaching Methods

Lectures, using slides and video. Theoretical and practical exercises.

Contacts/More Information

1) Readiness to offer individual assistance also in English language to incoming students
2) Availability of supporting material and bibliographic references also in english language.
List:.Epigenetics. Allis, Jenuwein, Reinberg and Caparros. Cold Spring Harbour Laboratory Press. ISBN-13:978-0879697242 |Edition:1
3) Readiness to accept examination of incoming students also in a foreign language (English)

Other courses

Course year: 1

BIOCHEMICAL METHODOLOGIES
6 credits - Caratterizzante
BIOCHEMISTRY AND INTERPLAY OF METABOLIC PATHWAYS
8 credits - Caratterizzante
CLINICAL MICROBIOLOGY
8 credits - Caratterizzante
ZOOLOGY
6 credits - Caratterizzante
MEDICAL GENETICS
6 credits - Affine/Integrativa
APPLIED MICROBIOLOGY AND VIROLOGY
4 credits - A scelta dello studente
TRAINING
10 credits - Altro

Course year: 2

FINAL TEST
35 credits
ADVANCED PHYSIOLOGY
6 credits - Caratterizzante
APPLIED HYGIENE
6 credits - Caratterizzante
EPIGENETICS AND GENE REGULATION
8 credits - Caratterizzante

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EPIGENETICS AND GENE REGULATION