Evolutionary meaning of "General Pathology"& and its evolution to "Molecular General Pathology".
1. Etiology of diseases: genetic disorders. Mutagens. Monogenic metabolic diseases: abnormalities of amino acids, proteins, sugars, lipids, mucopolysaccharides, purines, pyrimidines metabolilism;
Radiations; environment, diet as causes of pathology. Homeostasis.
Reversible and irreversible damages: Nuclear, REE, REL, Lysosomes, Mitochondria, PM reversible, Signaling pathways damages. Cell death: necrosis and apoptosis. Iperplasia, ipertrofy, metaplasia, atrophy, peroxiradicals and free radicals, aging. Intracellular & Extracellular damages: steatosis, Amiloidosis.
Inflammation, Immunobiology and immunopathology. Molecular mechanisms. Chemicals mediators. Acute & chronic inflammation. The Antibodies. The Complement. Lymphocytes B and T. Imunohystocompatible system.