PATHOLOGICAL ANATOMY

Integrated educational activity

Course Sheet

Academic Year of enrolment:

2017/2018

Optional/Mandatory:

Compulsory

Degree:

6-year Single Cycle Master's Degree Programme in MEDICINE AND SURGERY

Language:

Italian

Moduls:

NEUROLOGY

1 credits
PATHOLOGICAL ANATOMY

10 credits
INTERNSHIP

2 credits
GENERAL SURGERY

1 credits

Credits:

Programme Year:

Hours of classroom activity:

194

Prerequisites:

Having to learn the pathogenetic processes of diseases and the corresponding morphological, immunophenotypic and molecular lesions associated with them, it is necessary to have accurate knowledge of normal histology, normal human anatomy, human physiology, general pathology and genetics, in order to better understand the alterations of cells and tissues in the various pathological processes, by comparison with normal conditions.

AF code:

40000181

Assessment Methods

Verification of learning:

The final evaluation (exam) will take place in two stages
1) written test on the topics of the program (questions with multiple answers or, alternatively, development of an essay on given questions). Passing the written test will allow access to the second assessment phase.
2) Interview on the topics of the program.

There will also be a discussion under the microscope on histopathological specimens.

To pass the exam, the student must demonstrate that he or she has the required knowledge as a prerequisite, i.e.
1) detailed knowledge of normal macroscopic and microscopic anatomy and of physiology of organs and systems
2) basic knowledge of the pathologies covered by the course.
In particular, the student must demonstrate knowledge of each pathology: epidemiology, pathogenetic mechanisms, main macroscopic and histological characteristics of the lesions, prognostic and predictive factors, therapeutic approaches with related biomarkers and prognostic factors. The anatomopathological classifications will be required with a view to a correct therapeutic and prognostic classification.
The student must also be able to make the necessary reasoning for differential diagnoses in the various fields of human pathology.
The determination of the final grade therefore also takes into account the logical skills as well as the use of an appropriate language.

Enrollment for the exam takes place according to the online methods provided by the University.

Teaching period

First semester

Objectives

The course aims to provide the student with the tools to learn the anatomopathological basis of diseases of organs and systems and to be able to integrate macroscopic, cytological, histological and molecular morphological data into the clinical setting. The course will also describe the main diagnostic procedures and methods in pathological anatomy, the professional tasks, responsibilities and fields of activity of the anatomopathologist.

Contents

Knowledge of the malformative, dysmetabolic (congenital and acquired), circulatory, inflammatory and neoplastic (including preneoplastic lesions) pathologies of each of the organs / systems listed below is required:
• integumentary system
• skeletal and soft tissue systems
• cardio-vascular system
• central and peripheral nervous system
• lymphohemopoietic system
• endocrine system
• respiratory system and pleura
• female genital system and breast
• kidney and urinary tract
• male genital system
• digestive system and glandular structures attached to it.

Autoimmune diseases: Systemic Lupus Erythematosus, Sjogren's Syndrome, Scleroderma, Dermatomyositis, Mixed Connective Disease, Vasculitis.

Pathological anatomy of shock, heart failure and hypertension, diabetes of uremia and amyloidosis.

The knowledge required includes:
macroscopic findings,
histological findings,
clinical-pathological correlations,
natural history of pathologies with the highest epidemiological impact.

The study of tumors of the various organs and systems always includes knowledge of the following aspects: definition and classification, epidemiology, risk factors, diagnostic procedures, macro and microscopic aspect, grading and staging of the tumor, immunophenotypic profile (diagnostic markers), profile genetic-molecular including prognostic and predictive factors of therapeutic response, metastatic dissemination modality, evolution and prognosis.

General knowledge of the technical and organizational procedures of the diagnostic activity of Pathological Anatomy is required:
- Autopsy;
- Diagnostic techniques: histology, histochemistry, immunohistochemistry, morphometry, electron microscopy and molecular investigations;
- Techniques, applications and limits of cytological diagnostics (exfoliative, by apposition, by aspiration with thin needle);
- Request for histological examination and interpretation of the report;
- Indications and limits of the histological examination at the freezer (intraoperative);
- Clinical-pathological procedures and interaction in the management of organ transplants.

Recommended Bibliography

Robbins e Cotran "Le basi patologiche delle malattie - Patologia generale" vol.1, IX edizione. EDRA Editore
Robbins e Cotran "Le basi patologiche delle malattie - Malattie degli organi e degli apparati" vol.2, IX edizione. EDRA editore

R. Rubin, D.S. Strayer, "Anatomia patologica - Patologia d'organo e molecolare". Padova: Piccin Editore, 2014.

G.M Mariuzzi "Anatomia Patologica e correlazioni anatomo-cliniche". Padova: Piccin Editore, Ristampa 2017

Methods of Provision

Conventional

Teaching Methods

The didactic objective of the course is to make the student able to acquire knowledge and awareness of the clinical impact of Pathological Anatomy, with specific reference to the clinical-biological rationale of prevention interventions, diagnosis, therapy and prognosis of human pathology.
The course educates the student to the knowledge of macroscopic and histological lesions of human pathology with specific emphasis on the relationship between organic lesions, symptoms and clinical signs.
The course (divided into lectures and teaching in small groups) will deal only with some of the topics indicated in the program. This treatment will provide the student with the method for the autonomous study of the uncovered subjects.
The integration between teaching activity and personal study must allow the student to acquire the knowledge expected and consistent with the exercise of the medical profession.

Contacts/More Information

The teacher is available for interviews with students every day by appointment to be agreed by e-mail

PATHOLOGICAL ANATOMY

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PATHOLOGICAL ANATOMY