General information on drugs.
Definition of drug. Classification of drugs. Agonist and antagonist drugs. Inverse agonists and partial agonists. Biased ligand drugs. Allosteric modulators. Affinity and intrinsic activity of the drug. Dose-response curves. Effective dose 50. Toxic dose 50. Mathematical analysis of the dose response curves: Lineweaver-Burk.
Introduction to pharmacogenetics and pharmacogenomics.
Molecular basis of pharmacological selectivity.
Definition and classification of receptors. Receptor binding study methods: saturation and displacement curves.
Receptor theories: two-state conformational receptor theory and three-state conformational receptor theory. Reserve receptors. Down-regulation / desensitization and up-regulation of the receptor. Computational study methods for the three-dimensional structure of the receptor drug complex. Internalization of membrane receptors. Drug interactions (mechanisms). ADR: notes on the mechanisms of adverse drug reactions.
Molecular basis of the action of drugs on:
Ionotropic receptors: general characteristics of the GABAa receptor, glycine receptor (outline), acetylcholine receptor, glutamate receptors: NMDA, AMPA and kainate.
Metabotropic receptors: signal transduction. Second messengers general characteristics of receptors for catecholamines and dopamine. Muscarinic receptors, glutamate receptors, GABAB receptor. Voltage-dependent ion channels: general characteristics of channels for Na +, channels for K +, channels for Ca2 +,
Receptors for growth factors. Insulin receptor.
Intracellular or nuclear receptors
The pumps: sodium / potassium (structure, function, digoxin digitoxin and endogenous and exogenous ouabaine), protons in particular gastric H / K-ATPase.
Renin angiotensin aldosterone system
Biological drugs (antibodies: general information and some examples)
Nitrogen oxide and H2O2.
Arachidonic acid cascade.
Pharmacokinetics: absorption, distribution, metabolism and elimination (ADME), Drug delivery