Definition of Toxicological Chemistry and Poison. Factors that influence the toxicity of substances. Xenobiotic metabolism: Phase I reactions and Phase II reactions; mechanism of formation of reactive metabolites: electrophilous, nucleophile and radical species. Definition of toxico-phorus / structural alert. Factors influencing biotransformation (enzymatic inhibition of CYP-450 and enzymatic induction). Gene polymorphism.

Origin, presence, properties, uses, exposure, toxicokinetic and toxicodynamic properties of the following compounds:
Hydrocarbons. Alkanes: C1-C8 (hexane), C> 8. Alkenes: ethylene and ethylene oxide, 1,3-butadiene. Monocyclic aromatic hydrocarbons: benzene, toluene, xylenes, styrene. Polycyclic aromatic hydrocarbons: naphthalene, benzo [a] pyrene.
Organoalogenogenated compounds. Alkyl halides: dichloromethane, chloroform, carbon tetrachloride, 1,2-dibromoethane, 1,2-dichloroethane. Halogenated general anesthetics: halothane, methoxyflurane, isoflurane. Alkenyl halides: vinyl chloride. Aryl halides: polychlorobiphenyls (PCBs), dibenzofurans and dibenzodioxins.
Alcohols. Methanol, ethanol, ethylene glycol. Aspartame. Treatment of alcoholism (Disulfiram, Naloxone, Naltrexone).
Metals. Lead, mercury, arsenic, cadmium, chromium, nickel, cobalt, aluminum. Treatment of heavy metal poisoning (EDTA, dimercaprol, penicillamine).
Various chemical substances. Sodium / potassium cyanide, cyanogenic glycosides, carbon monoxide, isocyanates, methyl-isocyanate, phosgene, nitrites and nitrates, N-nitrosamines (dimethylnitrosamine, tobacco nitrosamines: NNK, NNN), aromatic amines (aniline, naphthylamine, benzidine), polycyclic heteroaromatic amines (imidazochinoline, imidazochinoxaline), furan, acrylamide, quinones and related compounds: steroidal estrogens (estradiol, estrone, equiline, equilenin), tamoxifen, safrole.
Pesticides. Traditional insecticides (DDT), carbamates (carbaryl, carbofuran, pirimicarb), organophosphates (mevinphos), organophosphates (parathion, diazinon), organoditiophosphates (malathion), organophosphonates (trichlorfon). Pyrethrum and pyrethroid. Treatment of intoxication by insecticides. Herbicides (chlorophenoxy compounds, bipyridyl derivatives, chloroacetanilides, triazines, phosphonomethyl amino acids).
Cannabis. Preparations derived from Cannabis. Phytocannabinoids (Δ9-THC, cannabinol, cannabidiol), synthetic cannabinoids: indoles (alkyl-naphthoylindoles, alkyl-phenylacetylindoles), pyrroles (alkyl-naphthoylpyrroles), pyrazoles (rimonabant). Synthetic cannabinoids (eg JWH-018, JWH-250) and the "Spice" phenomenon.
Smart Drugs. Smart Drugs associated with the "Spice" phenomenon (Nymphaea caerulea, Leonotis leonurus, Zornia latifolia).
Nicotiana tabacum. Nicotine. Toxicity of cigarette smoke.
Ergot alkaloids. Ergotamine, ergometrine, methylergometrine, bromocriptine.
Compounds with hallucinogenic activity. LSD, psilocybin / psilocin, mescaline, tryptamine.
Amfetamine (designer drugs). Amphetamine, methamphetamine, MDMA (ecstasy) and analogs (MDA, MDEA, MMDA).