CELLULAR PHARMACOLOGY AND TOXICOLOGY
Presentation of seminars (group-work) on topics freely choosen by presenters. This methodology allows direct evaluation of the learning process and achievements.
To inform students on the mechanism of action of drugs with particular reference to toxicity and side effects
Definitions of Toxicologies
Kinetic of toxics and poisons (routes of administration, absorption, distribution, metabolism, fate and escretion.
Dynamic of toxics and poisons (receptors, ion channels, enzimes, transcription factors etc.)
Methods in neurotoxicology: radioligands, optogenetics, etc
Agonism, antagonism, inverse-agonism,partial agonism, Kd, etc.
Drug dependence: definitions and neurobiology.
-Opioids
-Psicostimulants
-Alcohol
-Cannabinoids
-Nicotine
-Designer drugs
-Trattato di farmacologia di Lucio Annunziato e Gianfranco Di Renzo
-Goodman & Gilman's. The pharmacological basis of therapy
Teaching methodology is based on the principles of the Socratic debate (maieutics). In particular, fundamental aim of the course in Toxicology is to develop soft skills (critical reasoning, creative thinking, team work) to enable students to effectively navigate their environment, work well with others, perform well, and achieve their goals with complementing hard skills.
-Teaching material (PPT) available for students.
-Students are welcome to interact with the teacher to the end of each class.
Mandatory class attendance