CELLULAR PHARMACOLOGY AND TOXICOLOGY

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2017/2018

Type of Course:

Characterising

Optional/Mandatory:

Compulsory

Degree:

5-year Single Cycle Master's Degree Programme in PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY

Disciplinary Sector:

Pharmacology

Language:

Italian

Credits:

Programme Year:

Obligatory attendance:

Yes

Hours of classroom activity:

Prerequisites:

Human anatomy
Biochemistry
Physiology
General pathology
General pharmacology

Borrowed from

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TOXICOLOGY

PHARMACY

AF code:

40003646

Assessment Methods

Verification of learning:

Presentation of seminars (group-work) on topics freely choosen by presenters. This methodology allows direct evaluation of the learning process and achievements.

Teaching period

Second semester

Objectives

To inform students on the mechanism of action of drugs with particular reference to toxicity and side effects

Contents

Definitions of Toxicologies

Kinetic of toxics and poisons (routes of administration, absorption, distribution, metabolism, fate and escretion.

Dynamic of toxics and poisons (receptors, ion channels, enzimes, transcription factors etc.)

Methods in neurotoxicology: radioligands, optogenetics, etc

Agonism, antagonism, inverse-agonism,partial agonism, Kd, etc.

Drug dependence: definitions and neurobiology.

-Opioids
-Psicostimulants
-Alcohol
-Cannabinoids
-Nicotine
-Designer drugs

Recommended Bibliography

-Trattato di farmacologia di Lucio Annunziato e Gianfranco Di Renzo
-Goodman & Gilman's. The pharmacological basis of therapy

Methods of Provision

Conventional

Teaching Methods

Teaching methodology is based on the principles of the Socratic debate (maieutics). In particular, fundamental aim of the course in Toxicology is to develop soft skills (critical reasoning, creative thinking, team work) to enable students to effectively navigate their environment, work well with others, perform well, and achieve their goals with complementing hard skills.

Contacts/More Information

-Teaching material (PPT) available for students.
-Students are welcome to interact with the teacher to the end of each class.
Mandatory class attendance

CELLULAR PHARMACOLOGY AND TOXICOLOGY

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CELLULAR PHARMACOLOGY AND TOXICOLOGY