The goal of the course is to provide the student with basic notions for the understanding of the neoplastic pathologies focusing on the mechanisms of transformation, invasion and metastasis.
During lab practice exercises, methodological approaches necessary for the study of the molecular mechanisms regarding neoplasia will be utilized, considering the aspects of research and also the clinical – diagnostic applications and prognostic and therapeutic implications.
Moreover, provide notions about the molecular processes underlying isolation, culturing and differentiation of stem cells. Particular emphasis will be placed on the molecular characterization, and on the molecular mechanisms responsible for maintaining the pluripotency / multipotency and for cell differentiation. The main biological characteristics of mesenchymal stem cells and induced pluripotent cells (IPS) and the principles that lie at the basis of their potential applications will be further dissected. Finally the main mode of clinical application of stem cells will be illustrated, and results described in the literature will be analyzed.