Introduction to the experimental animal model. D.L. 26, 2014 on the protection of animals used for scientific research. Surgical procedures on experimental animals. Methodologies used for preclinical studies in laboratory animals. Experimental models of hypertension. Animal models for the study of pain. Animal models of acute and chronic inflammation. Methods for the study of diuretic, choleretic and laxative activity. Models used to evaluate memory and learning. Experimental models used in anxiety disorders. Animal models of stress. Experimental models of depression. Animal models for the study of substance addiction. Animal models in the study of neurodegenerative diseases.
Introduction to the chemistry of the central nervous system. Dopaminergic system and dopaminergic nerve pathways. The nerve path of pleasure and reward. Dopamine and feeding. Dopamine and addiction. Dopamine and movement. Neurological disorders related to dopamine. Psychiatric disorders linked to dopamine. Serotoninic, noradrenergic transmission system and depression. Glutametergic and GABAergic transmission system. Epilepsy, anxiety and surgical anesthesia and drugs. The meaning and neurochemistry of sleep. Pediatric, mixed and neuropathic pain. Brain opioidergic system and pain therapy. Cholinergic system and Alzheimer's disease. Definition and principles of operation of neurosensors. Microsensors and biosensors. Classification of biosensors and main signal transduction mechanisms. Characteristics of biosensors for the study of in vivo neurochemistry. Design and characterization of implantable microsensors and biosensors.