1. Historical sketch of Italian regionalism: its birth, the implementation of the ordinary Regions from the first transfer of functions to the so-called "Administrative federalism", and the constitutional reforms of the years 1999-2001; 2. Legislative autonomy: the exclusive competence of the State, the concurrent legislation, the residual legislative power of the Regiona and the so-called "legislative subsidiarity"; 3. The matters of exclusive competence, the matters of concurrent competence and those of residual competence; 4. Regulatory powers of State and Regions; 5. The path of administrative autonomy from the principle of parallelism to the principle of subsidiarity; 4. The financial autonomy; 5. The constitutional status of the smaller territorial autonomies; 6. The instruments of interinstitutional collaboration between State and territorial autonomies; 7. The special Regions; 8. The so-called “Differentiated regionalism” enshrined in the art. 116, third paragraph, of the Italian Constitution; 9. The constitutional reform of the Senate and the autonomy system: problems and perspectives.