PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY I

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2018/2019

Type of Course:

Characterising

Optional/Mandatory:

Compulsory

Degree:

5-year Single Cycle Master's Degree Programme in PHARMACY

Disciplinary Sector:

Pharmaceutical Chemistry

Language:

Italian

Credits:

Programme Year:

Professor and Collaborators:

PINNA Gerard Aime

Obligatory attendance:

Yes

Hours of classroom activity:

Prerequisites:

To have passed the course exams of Organic Chemistry, Heterocyclic Chemistry, Biochemistry, and Pharmacognosy.

AF code:

40000850

Assessment Methods

Verification of learning:

Oral exam.

Teaching period

First semester

Objectives

The course unit of Medicinal and Toxicological 1 provides formative and informative criteria suitable for the study of drugs describing not only chemical and biological aspects but also the therapeutical uses. A preliminary part of the course unit is used to outline the general medicinal chemistry which represents the groundwork of course and deals with the drug design and development based on pharmacodynamic and pharmacokinetic principles. A second part of the course includes a sistematic component encompassing the study of chemotherapy and hormonotherapy.

Contents

Introduction to the course unit of Med.and Tox. chemistry 1. Historical outlines . Drug design process. Discovery of the lead compound: empirical and rational approches. Lead optimization: SAR, QSAR and CADD. Pharmacodynamics: molecular mechanisms of drug action. Pharmacokinetics: ADME process and drug metabolism. Chemotherapy: antibacterial, antiprotozoal, antifungal, antiviral and antiretroviral drugs; anticancer drugs. Corticosteroids: biosynthesis, semi-synthesis and nomenclature. Oestrogen drugs. Progestogen drugs. Androgen drugs. Corticosteroid drugs.

Recommended Bibliography

R.B. Silverman: The organic chemistry of drug design and drug action. 3th Edition. 2044.
T.M. Lemke, D.A. Williams, V.F. Roche, S. W. Zito: Foye's Principles of medicinal chemistry. 8th Edition.2020
T.L. Lemke, S.W. Zito, V.F. Roche, D.A. William: Essentials of Foye's principles of medicinal chemistry. 2017.
G.L. Patrick: An introduction to medicinal chemistry. 6th Edition, 2017
A. Gasco, F. Gualtieri, C. Melchiorre: Chimica Farmaceutica.2020.

Methods of Provision

Conventional

Teaching Methods

The use of slides containing a lot of figures and schemes during the lectures. The schemes and figures provides maximum information as concisely as possible.

Contacts/More Information

Readiness to offer individual assistance also in English and French language to incoming students.
Availability of supporting material and bibliographic references also in english language.
List: Burger's Medicinal chemistry, drug discovery, and development. 7th Edition. Edited by Donald J. Abraham and David P. Rotella. Vol 1-7.
Readiness to accept examination of incoming students also in a foreign language (English and French).

Other courses

Course year: 1

GENERAL AND INORGANIC CHEMISTRY
10 credits - Base
HUMAN ANATOMY WITH ELEMENTS OF ANIMAL BIOLOGY
10 credits - Base
MATHEMATICS WITH ELEMENTS OF COMPUTER SCIENCE AND STATISTICS
7 credits - Base
MICROBIOLOGY
6 credits - Base
PHARMACEUTICAL BOTANY WITH ELEMENTS OF PLANT BIOLOGY
9 credits - Base
PHYSICS
6 credits - Base
CLINICAL BIOCHEMISTRY
4 credits - A scelta dello studente
CLINICAL PHARMACY
4 credits - A scelta dello studente
ENGLISH
5 credits - Lingua/Prova Finale
OTHER TRAINING ACTIVITIES
2 credits - Altro

Course year: 2

ANALYTICAL CHEMISTRY
6 credits - Base
HYGIENE AND HEALTH EDUCATION
8 credits - Base
ORGANIC CHEMISTRY
12 credits - Base
BIOCHEMISTRY
10 credits - Caratterizzante
HETEROCYCLIC PHARMACEUTICAL CHEMISTRY
6 credits - Caratterizzante

Course year: 3

GENERAL PATHOLOGY WITH ELEMENTS OF MEDICAL TERMINOLOGY
8 credits - Base
GENERAL PHYSIOLOGY
10 credits - Base
GENERAL PHARMACOLOGY
10 credits - Caratterizzante
MEDICAL APPLIED BIOCHEMISTRY
9 credits - Caratterizzante
MORPHOLOGY AND DIAGNOSTICS OF MEDICINAL DRUGS AND PHYTOCOMPLEXES
9 credits - Caratterizzante
QUANTITATIVE PHARMACEUTICAL ANALYSIS
10 credits - Caratterizzante
TOXICOLOGY
8 credits - Caratterizzante

Course year: 4

PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY I
12 credits - Caratterizzante
PHARMACEUTICAL TECHNOLOGY 1
6 credits - Caratterizzante
PHARMACOLOGY, PHARMACOGNOSY AND PHARMACOTHERAPY
10 credits - Caratterizzante
QUALITATIVE ANALYSIS OF DRUGS
12 credits - Caratterizzante
SOCIO-ECONOMICS AND DRUG REGULATORY AFFAIRS
6 credits - Caratterizzante
TOXICOLOGICAL CHEMISTRY
6 credits - Affine/Integrativa
TRAINING
15 credits - Per stages e tirocini

Course year: 5

FINAL TEST
15 credits
NUTRACEUTICAL-FOOD CHEMISTRY
6 credits - Caratterizzante
PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY II
12 credits - Caratterizzante
PHARMACEUTICAL TECHNOLOGY 2 AND GALENIC LABORATORY
10 credits - Caratterizzante
FORMULATION AND LEGISLATION OF COSMETIC PRODUCTS
6 credits - Affine/Integrativa
TRAINING
15 credits - Per stages e tirocini

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PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY I