Elements of general, inorganic and organic chemistry. The macromolecules of biological interest. Water. Carbohydrates. Protides. Lipids. Vitamins. Biological membranes. Nucleic acids. Bioenergetics. Carboxylic metabolism and its regulation (glycolysis, pentosophosphate shunt, tricarboxylic acid cycle, gluconeogenesis).Electron transport chain and oxidative phosphorylation. Metabolism of amino acids and proteins, metabolism of lipids. Cell redox state and reactive oxygen species. The enzymes. Integration of metabolism and hormonal regulation. Biosignaling.