GREEN ORGANIC CHEMISTRY

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2021/2022

Type of Course:

Related/Supplementary

Optional/Mandatory:

Compulsory

Degree:

Master's Degree Programme in CHEMICAL SCIENCES

Disciplinary Sector:

Organic Chemistry

Language:

Italian

Credits:

Programme Year:

Professor and Collaborators:

CARRARO Massimo

Hours of classroom activity:

Prerequisites:

It is required a basic knowledge of chemical reactivity acquired in fundamental organic chemistry courses, such as:
Atomic orbitals
Aufbau
Lewis structures
Hybridization of carbon
Formalism of curved arrows, balance, resonance
Acids, bases, electrophiles, nucleophiles
Inductive and mesomeric effects
Nucleophilic substitutions, aromatic electrophiles substitutions
Additions, eliminations

AF code:

A001181

Assessment Methods

Verification of learning:

The exam is based on the elaboration and discussion of a presentation focused on the synthesis of a specific compound (assigned by the teacher), describing various synthetic pathways that highlight the aspects of low environmental impact using chemical metrics and the knowledge learned during the course .

Teaching period

Second semester

Objectives

The course aims to provide an overview of "Green Chemistry" thus, development of chemical processes and techniques under low environmental impact and low risk conditions and with a high sustainability. The aspects connected with organic chemistry will be examined and therefore chemical metrics in synthesis, solvents, catalysis, raw materials from renewable sources and innovative techniques in particular applied to the synthesis of fine chemicals and pharmaceutical products, with application in the laboratory part. At the end of the course the student must be able to compare and evaluate synthesis of organic compounds with a critical view and to elaborate and propose simple alternatives according to the criteria discussed in class.

Contents

The twelve principles of Green Chemistry. Green chemistry metrics. Solvents in organic synthesis: life cycle and parameters that characterize them. Solventless reactions. Alternative solvents: water; biphasic systems; fluorinated liquids; supercritical fluids; Supercritical CO2 and CXL; ionic liquids (RTILs and DES); solvents from renewable sources. Catalysis with acids and solid bases. Reductions and catalyzed oxidations: use of H2 and O2. Catalyzed formations of C-C bonds and building blocks with high atomic economy. Asymmetric synthesis and organocatalysis. Shape selective catalysis: zeolites and cyclodextrins. Biocatalysis. Borrowing hydrogen. Microfluidics. Photochemistry. Mechanochemistry, sonochemistry and microwaves. Circular economy and raw materials from renewable sources.

Recommended Bibliography

- Green Chemistry Metrics A Guide to Determining and Evaluating Process Greenness, Andrew Dicks and Andrei Hent, Springer
- Green Chemistry: An Introductory Text, 3rd edition; Mike Lancaster, RSC, ISBN 978-1-78262-294-9
- Introduction to Green Chemistry, Albert S. Matlack, CRC Press, ISBN 978-1-4398-8211-5
- Green Organic Chemistry in Lecture and Laboratory, Andrew P. Dicks, CRC Press, ISBN-13: 978-1439840764

Methods of Provision

Conventional

Teaching Methods

32 hours of lecture and 32 hours of laboratory

Contacts/More Information

The teacher is available, on request, to provide:
1) a tutoring service also in English for Erasmus/foreign students
2) didactic material and bibliographical references in English
3) exams in a foreign language (English)

Other courses

Course year: 1

ADVANCED INORGANIC CHEMISTRY
6 credits - Caratterizzante
ADVANCED MACROMOLECULAR CHEMISTRY
8 credits - Caratterizzante
ADVANCED ORGANIC CHEMISTRY
8 credits - Caratterizzante
ANALYTICAL CHEMISTRY
6 credits - Caratterizzante
APPLIED ELECTROANALYTICAL CHEMISTRY
6 credits - Caratterizzante
ORGANOMETALLIC CHEMISTRY
6 credits - Caratterizzante
PHYSICAL CHEMISTRY
6 credits - Caratterizzante
SPECTROSCOPY AND STRUCTURAL CHEMISTRY
6 credits - Caratterizzante
GREEN ORGANIC CHEMISTRY
6 credits - Affine/Integrativa
COMPUTATIONAL CHEMISTRY
4 credits - A scelta dello studente
ENGLISH LANGUAGE
4 credits - Altro

Course year: 2

FINAL TEST
40 credits
NANOMATERIALS AND NANOTECHNOLOGIES
4 credits
COMPUTATIONAL CHEMISTRY
4 credits - Affine/Integrativa
ELEMENTS OF HETEROGENEOUS CATALYSIS
4 credits - Affine/Integrativa
ENVIRONMENTAL LAW AND ANALYSIS OF POLLUTING SYSTEMS
4 credits - Affine/Integrativa
LABORATORY OF MACROMOLECULAR SYNTHESIS
4 credits - Affine/Integrativa
MATERIALS AND TECHNOLOGY IN CULTURAL HERITAGE
4 credits - Affine/Integrativa
METALS IN MEDICINE
4 credits - Affine/Integrativa
PHYSICAL METHODS FOR CULTURAL HERITAGES
4 credits - Affine/Integrativa
SENSORS FOR ANALYTICAL CHEMISTRY
4 credits - Affine/Integrativa
TRAINING
2 credits - Altro

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GREEN ORGANIC CHEMISTRY