Toxicology definition and general principles (ionic channels, receptors, dse-response relationship etc). Kinetic of poisons (administration routes, absorbtion, distribution, pharmacodynamics, metabolism and fate, escretion). Agonists, antagonists, partial agonists. Drugs of abuse and addiction (principles) and pathologies induced by administration of chemicals (opioids, psychostimulants, alcool, nicotine, ecstasy etc) and not (sex-internet-gambling). Principles of experimental therapies.