Introduction to the course unit of Med.and Tox. chemistry 1. Historical outlines . Drug design process. Discovery of the lead compound: empirical and rational approches. Lead optimization: SAR, QSAR and CADD. Pharmacodynamics: molecular mechanisms of drug action. Pharmacokinetics: ADME process and drug metabolism. Chemotherapy: antibacterial, antiprotozoal, antifungal, antiviral and antiretroviral drugs; anticancer drugs. Corticosteroids: biosynthesis, semi-synthesis and nomenclature. Oestrogen drugs. Progestogen drugs. Androgen drugs. Corticosteroid drugs.