ADVANCED PHARMACEUTICAL CHEMISTRY
Final oral exam
The course unit of Medicinal and Pharmaceutical Chemistry 2 aims at enabling the student to become familiar with the structure, the structure-activity-relationships, the chemical-physical and stereo-electronic properties, the synthesis, the mechanism of action , the metabolism, the adverse effects, the incompatibilities, and the therapeutic use of the drugs under study.
- Drugs of the ANS: parasympathomimetics, parasympatholytic, sympathomimetic, sympatholytic.
- Drugs CNS: sedative-hypnotics, anticonvulsants, skeletal muscle relaxing, anti-Parkinson, antipsychotics, anxiolytics, antidepressants, hallucinogen-stimulants.
- Drugs used in the treatment of pain: NSAIDs, local anesthetics, general anesthetics, opioids, antigout.
- Cardiovascular and Renal Drugs: antihypertensives, vasodilators and antianginals, cardiotonics, antiarrhythmic agents, diuretics.
- Drugs for pulmonary diseases.
- Antihistaminic drugs.
- Antiulcer drugs
- “Chimica Farmaceutica”, I Ed., Gasco, Gualtieri, Melchiorre. Casa Editrice Ambrosiana (ISBN: 978-88-08-18712-3)
-“Foye’s Principles of Medicinal Chemistry”, VII Ed., Thomas L. Lemke, David A. Williams. Lippincott Williams & Wilkins (ISBN: 978-1-4511-7572-1)
- “Pharmaceutical Substances”. IV Ed. Axel Kleeman, Jurgen Engel. Thieme (ISBN: 1-5889-0031-2)
- “Strategic Applications of Named Reactions in Organic Synthesis”. László Kürti, Barbara Czakó. Elsevier Academic Press (ISBN: 0-12-429785-4)
- “Goodman & Gilman’s. The Pharmacological Basis of Therapeutics” XII Ed., Brunton, Chabner, Knollman, McGraw Hill (ISBN: 978-0-07-162442-8)
Power Point presentation, blackboard and molecular models
1) Readiness to offer individual assistance also in English language to incoming students
2) Availability of supporting material and bibliographic references also in english and french language. List:Lemke, Williams, Foye’s Principles of Medicinal Chemistry, 7th Ed., Lippincott Williams & Wilkins.
- Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins
- Kleemann, Engel, Kutscher, Reichert, Pharmaceutical Substances, 5th Ed., Thieme Verlag.
- Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th Ed., McGraw-Hill Medical Publishing Division.
- Claiden, Greeves, Warren, Organic Chemistry, 2nd Ed., Oxford University Press
3) Readiness to accept examination of incoming students also in a foreign language (English)