ADVANCED PHARMACEUTICAL CHEMISTRY

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2013/2014

Type of Course:

Characterising

Optional/Mandatory:

Compulsory

Degree:

5-year Single Cycle Master's Degree Programme in PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY

Disciplinary Sector:

Pharmaceutical Chemistry

Language:

Italian

Credits:

Programme Year:

Obligatory attendance:

Yes

Hours of classroom activity:

Prerequisites:

To have passed the exam of the course of Medicinal and Toxicological Chemistry I (for students of Pharmacy) and Advanced chemistry (for CTF)

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PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY II

PHARMACY

AF code:

40000849

Assessment Methods

Verification of learning:

Final oral exam

Teaching period

First semester

Objectives

The course unit of Medicinal and Pharmaceutical Chemistry 2 aims at enabling the student to become familiar with the structure, the structure-activity-relationships, the chemical-physical and stereo-electronic properties, the synthesis, the mechanism of action , the metabolism, the adverse effects, the incompatibilities, and the therapeutic use of the drugs under study.

Contents

- Drugs of the ANS: parasympathomimetics, parasympatholytic, sympathomimetic, sympatholytic.
- Drugs CNS: sedative-hypnotics, anticonvulsants, skeletal muscle relaxing, anti-Parkinson, antipsychotics, anxiolytics, antidepressants, hallucinogen-stimulants.
- Drugs used in the treatment of pain: NSAIDs, local anesthetics, general anesthetics, opioids, antigout.
- Cardiovascular and Renal Drugs: antihypertensives, vasodilators and antianginals, cardiotonics, antiarrhythmic agents, diuretics.
- Drugs for pulmonary diseases.
- Antihistaminic drugs.
- Antiulcer drugs

Recommended Bibliography

- “Chimica Farmaceutica”, I Ed., Gasco, Gualtieri, Melchiorre. Casa Editrice Ambrosiana (ISBN: 978-88-08-18712-3)
-“Foye’s Principles of Medicinal Chemistry”, VII Ed., Thomas L. Lemke, David A. Williams. Lippincott Williams & Wilkins (ISBN: 978-1-4511-7572-1)
- “Pharmaceutical Substances”. IV Ed. Axel Kleeman, Jurgen Engel. Thieme (ISBN: 1-5889-0031-2)
- “Strategic Applications of Named Reactions in Organic Synthesis”. László Kürti, Barbara Czakó. Elsevier Academic Press (ISBN: 0-12-429785-4)
- “Goodman & Gilman’s. The Pharmacological Basis of Therapeutics” XII Ed., Brunton, Chabner, Knollman, McGraw Hill (ISBN: 978-0-07-162442-8)

Methods of Provision

Conventional

Teaching Methods

Power Point presentation, blackboard and molecular models

Contacts/More Information

1) Readiness to offer individual assistance also in English language to incoming students
2) Availability of supporting material and bibliographic references also in english and french language. List:Lemke, Williams, Foye’s Principles of Medicinal Chemistry, 7th Ed., Lippincott Williams & Wilkins.
- Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins
- Kleemann, Engel, Kutscher, Reichert, Pharmaceutical Substances, 5th Ed., Thieme Verlag.
- Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th Ed., McGraw-Hill Medical Publishing Division.
- Claiden, Greeves, Warren, Organic Chemistry, 2nd Ed., Oxford University Press
3) Readiness to accept examination of incoming students also in a foreign language (English)

Other courses

Course year: 1

GENERAL AND INORGANIC CHEMISTRY AND STOICHIOMETRY
14 credits - Base
HUMAN ANATOMY WITH ELEMENTS OF ANIMAL BIOLOGY
9 credits - Base
MATHEMATICS
8 credits - Base
PHYSICS
8 credits - Base
PLANT BIOLOGY
6 credits - Base
OPTIONAL ACTIVITIES FIRST YEAR
4 credits - A scelta dello studente
OTHER TRAINING ACTIVITIES
1 credits - Altro

Course year: 2

ANALYTICAL CHEMISTRY
6 credits - Base
MICROBIOLOGY WITH ELEMENTS OF MEDICAL TERMINOLOGY
10 credits - Base
ORGANIC CHEMISTRY
10 credits - Base
BIOLOGICAL CHEMISTRY
10 credits - Caratterizzante
INORGANIC QUALITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
6 credits - Caratterizzante
PHARMACOGNOSY
6 credits - Caratterizzante
PHYSICAL CHEMISTRY
6 credits - Affine/Integrativa
ENGLISH
3 credits - Lingua/Prova Finale

Course year: 3

PHYSIOLOGY
9 credits - Base
APPLIED BIOCHEMISTRY
9 credits - Caratterizzante
CELLULAR PHARMACOLOGY AND TOXICOLOGY
10 credits - Caratterizzante
CHEMICAL ANALYSIS OF FOOD
6 credits - Caratterizzante
QUANTITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
9 credits - Caratterizzante
ADVANCED ORGANIC CHEMISTRY
8 credits - Affine/Integrativa
PHYSICAL METHODS IN ORGANIC CHEMISTRY
7 credits - Affine/Integrativa

Course year: 4

LABORATORY OF DRUGS EXTRACTION AND SYNTHESIS PREPARATION
10 credits - Caratterizzante
ORGANIC QUALITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
9 credits - Caratterizzante
PHARMACEUTICAL CHEMISTRY
10 credits - Caratterizzante
PHARMACOLOGY AND PHARMACOTHERAPY
11 credits - Caratterizzante
TECHNOLOGY, SOCIOECONOMICS AND PHARMACEUTICAL LEGISLATION
12 credits - Caratterizzante
TRAINING
15 credits - Per stages e tirocini

Course year: 5

FINAL TEST
26 credits
ADVANCED PHARMACEUTICAL CHEMISTRY
9 credits - Caratterizzante
APPLIED PHARMACEUTICAL CHEMISTRY
8 credits - Caratterizzante
PHARMACEUTICAL INDUSTRIAL PLANTS
6 credits - Caratterizzante
TRAINING
15 credits - Per stages e tirocini

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ADVANCED PHARMACEUTICAL CHEMISTRY