PHARMACEUTICAL CHEMISTRY

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2013/2014

Type of Course:

Related/Supplementary

Optional/Mandatory:

Optional

Degree:

Master's Degree Programme in CHEMICAL SCIENCES

Disciplinary Sector:

Pharmaceutical Chemistry

Credits:

Programme Year:

Professor and Collaborators:

SECHI Mario

Hours of classroom activity:

Prerequisites:

No prerequisites

AF code:

40000931

Assessment Methods

Verification of learning:

Ongoing written test and final oral exam

Teaching period

First semester

Objectives

This course focuses on the fundamental aspects and current methodologies involved in the drug discovery process, with particular emphasis on the modern and rational approaches used in the “Drug Design and Discovery”. Moreover, students will have a knowledge of the molecular basis of pharmacological activity of major classes of therapeutic agents, and be familiar with the design of novel drug prototypes and their targeted delivery toward specific biological targets.

Contents

Introduction to Medicinal Chemistry. The biomacromolecules as drug targets. The drug discovery and development. Drug design and ligand-receptor interation. The Drug Design. Pharmacokinetic and pharmacodinamic. Molecular Modelling: the role of computational methods on rational drug design of novel bioactive molecules. Drug delivery and pharmaceutical technologies. Nano(bio)technology on Drug Discovery: towards Nanomedicine. The drug development process. Clinical trials. New perspectives on Drug Discovery: from genomic to proteomic. Informations on the major classes of therapeutic agents.

Recommended Bibliography

- Graham L. Patrick. An Introduction to Medicinal Chemistry (2013) Fifth Edition . Oxford University Press.
- Curiosity: Montagnon, Tamsyn - Molecules That Changed the World - Wiley-VCH, 2008-
- Teaching material such as slides, reviews, and software, is available

Teaching Methods

- Lectures to the classroom by projector. Slides were prepared in Power Point format.
- Interactive computer-based learning suite by Molecular ConceptorTM -Synergixsoftware package.
- Exercitation in computer room by using computational programs for drug design (ex. biomolecules visualization, virtual screening, docking).
- Exercitation in laboratory: experiments will be focused on the preparation of drug prototypes and novel nanosystems.

Contacts/More Information

1) Readiness to offer individual assistance also in English language to incoming students
2) Availability of supporting material and bibliographic references also in english language.
List:- Graham L. Patrick. An Introduction to Medicinal Chemistry (2013) Fifth Edition . Oxford University Press.
- Slides and reviews on nanobiotechnogy are available
- Curiosity: Montagnon, Tamsyn - Molecules That Changed the World - Wiley-VCH, 2008

3) Readiness to accept examination of incoming students also in a foreign language (English)

Other courses

Course year: 1

CHIMICA ORGANICA SUPERIORE
8 credits - Caratterizzante
ELECTROANALYTICAL CHEMISTRY
8 credits - Caratterizzante
INORGANIC CHEMISTRY
8 credits - Caratterizzante
PHYSICAL CHEMISTRY
8 credits - Caratterizzante
POLLUTION CHEMISTRY
6 credits - Caratterizzante
SPECTROSCOPY AND STRUCTURAL CHEMISTRY
6 credits - Caratterizzante
BIO INORGANIC CHEMISTRY
6 credits - Affine/Integrativa
INNOVATIVE MATERIALS FOR ENERGY
6 credits - Affine/Integrativa
METHODOLOGIES IN INORGANIC CHEMISTRY
6 credits - Affine/Integrativa
PHARMACEUTICAL CHEMISTRY
6 credits - Affine/Integrativa
PHYSICAL METHODS IN ORGANIC CHEMISTRY
6 credits - Affine/Integrativa
MS-INTERFACE SYSTEMS IN THE INSTRUMENTAL CHEMICAL ANALYSIS
4 credits - A scelta dello studente

Course year: 2

FINAL TEST
40 credits
INDUSTRIAL AND POLYMER CHEMISTRY (ADVANCED COURSE)
8 credits - Caratterizzante
INTRODUCTION TO MATERIALS SCIENCE AND TO NANOMATERIALS CHEMISTRY
6 credits - Affine/Integrativa
ORGANIC SYNTHESIS AND LOW ENVIRONMENTAL IMPACT TECHNIQUES
6 credits - Affine/Integrativa
THEORETICAL CHEMISTRY
6 credits - Affine/Integrativa
TRAINING
2 credits - Altro

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PHARMACEUTICAL CHEMISTRY