ORGANIC SYNTHESIS AND LOW ENVIRONMENTAL IMPACT TECHNIQUES
The exam is based on the elaboration and discussion of a presentation focused on the synthesis of a specific compound (agreed with the teacher), describing various synthetic routes that highlight aspects of low environmental impact using the knowledge learned during the course.
This course is designed to provide an overview of "Green Chemistry", ie the development of processes and chemical techniques with low environmental impact, low-risk and high sustainability. The aspects emphasized in this course are those associated with organic synthesis and thus chemistry metrics, solvents, catalysis and innovative techniques in particular applied to the synthesis of fine chemicals and pharmaceuticals, with a laboratory module. At the end of the course the student will be able to compare and evaluate the synthesis of organic compounds with a critical spirit and to develop and propose simple alternatives according to the criteria discussed in class.
The twelve principles of Green Chemistry. Chemistry metrics. Solvents in organic synthesis: life cycle and solvent parameters. Solventless reactions. Alternative solvents: water; biphasic systems; fluorinated liquids; supercritical fluids; supercritical CO2 and CXL; ionic liquids (RTILs and DES); solvents from renewable resources. Concept of catalyst. Catalysis by solid acids and bases. Catalyzed reductions and oxidations: the use of H2 and O2. Catalyzed C-C bond formations and building blocks with high atom economy. Asymmetric synthesis and organocatalysis. Shape selective catalysis: zeolites and cyclodextrins. Biocatalysis. Microfluidics. Photochemistry. Mechanochemistry, microwave and sonochemistry. Chemicals from renewable sources.
Green Organic Chemistry in Lectures and Laboratory; Andrew P.Dicks; CRC Press; ISBN-13: 978-1439840764.
Green Organic Chemistry: Strategies, Tools, and Laboratory Experiments; Kenneth M.Doxsee, James Hutchinson; Brooks/Cole; ISBN-13: 978-0534388515
The lesson slides will be available.
24 hours of lectures and 48 hours of laboratory experiments.
1) Readiness to offer individual assistance also in English language to incoming students
2) Availability of supporting material and bibliographic references also in english language.
List:Green Organic Chemistry in Lectures and Laboratory; Andrew P.Dicks; CRC Press; ISBN-13: 978-1439840764.
Green Organic Chemistry: Strategies, Tools, and Laboratory Experiments; Kenneth M.Doxsee, James Hutchinson; Brooks/Cole; ISBN-13: 978-0534388515
3) Readiness to accept examination of incoming students also in a foreign language (English)