Course introduction. Carbohydrates, Nucleotides, Lipids: review of structure, nomenclature, physical properties. Peptides: chemistry, structure of the peptide bond, biological activities of peptides; Protein structure; primary, secondary, tertiary and quaternary. Protein function: ligand binding; allostery; regulation. Enzyme mechanisms; Enzyme regulation: allosteric and covalent. Membranes. Principles of bioenergetics: free-energy changes in biology. Introduction to metabolism. ATP and phosphoryl group transfers: chemistry and biology. Glycolysis, gluconeogenesis, glycogen metabolism and metabolic regulation. Pyruvate oxidation and the citric acid cycle; oxidation of fatty acids. ATP synthesis coupled to mitochondrial electron transfer.