At the end of this course, the student will know the role of biochemical parameters in the diagnostic of the human healtd status.The student will be able to know and manage: the role of the biochemical parameters that are the basis of inherited and acquired genetic diseases; the laboratory process and quality control system, the clinical molecular biology methodologies for the assessment of disease susceptibility. The EBLM approach. The coagulation diagnostic strategies, the liver function and liver diseases, the vascular and cardiovascular risk factors, endocrine, autoimmune, metabolic disorders, and renal disease