The fundamentals of anatomy, physiology, clinical and instrumental semeiotic, complications, treatment and follow-up of Dyspeptic Sindrome, Peptic Ulcer: NSAIDSs GI toxicity and Helicobacter pylori infection, Constipation, bacterial Overgrowth, Acut and Chronic Pancreatitis, Gallstones disease, and Indications for upper endoscopy will be illustrated.