QUANTITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2014/2015

Type of Course:

Characterising

Optional/Mandatory:

Compulsory

Degree:

5-year Single Cycle Master's Degree Programme in PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY

Disciplinary Sector:

Pharmaceutical Chemistry

Credits:

Programme Year:

Professor and Collaborators:

BOATTO Gianpiero

Hours of classroom activity:

102

Prerequisites:

Organic Chemistry, Pharmaceutical Chemistry: Inorganic Qualitative Analysis, Analytical Chemistry

AF code:

40003645

Assessment Methods

Verification of learning:

The assessment of learning tends to ensure the achievement of the teaching objectives by the knowledge of chemical and instrumental methods of quantitative analysis. The students must pass the exam through an oral final examination.

Teaching period

First semester

Objectives

The subject of the course is quantitative analysis applied in the pharmaceutical field, performed through the use of chemical and instrumental methods. It provides the theoretical and practical basis that is fundamental for the main techniques used in quantitative analysis of drugs. Through the knowledge and use of various analytical methodologies, students acquire the manual skills and experience for the correct solution of diverse analytical problems. At the end of the course, which include laboratory exercises in a single place, the student will possess knowledge of methods of quantitative analysis, volumetric and instrumental, reported in the monographs of the European Pharmacopoeia.

Contents

The teaching program comprises a theoretical part, which imparts a knowledge of the chemical and instrumental analytical techniques for quantitative measurement and determination of the purity of pharmaceutical substances. It is followed by an applied part, during which the notions learnt are put into practice. The chemical techniques include volumetric analyses realised by: acid and base neutralization, precipitimetric titrations, redox titrations, complexometric titrations. The instrumental techniques include quantitative analyses employing: potentiometry, spectroscopy (UV-VIS), analytical separations (GC, HPLC, CE). The applied part consists of 23 practical exercises of the European Pharmacopeia.

Recommended Bibliography

Lecture notes, are available at the library of the Chemistry and Pharmacy Department or slides provided by the teacher.
1) Abignente,D. Melisi, M.G. Rimoli. Principi di Analisi Quantitativa dei Medicinali (Teoria, Pratica ed eserciziario). Ed. Loghia Napoli, 2008.
2) D. C. Harris: “Quantitative Chemical Analysis”. 8th Ed. W.H. Freeman and Company
3) D. Skoog e D. West, FJ Holler: “Fundamentals of Analytical Chemistry”, Saunders College Publ. third edition.
4) D. Skoog e J.J. Leary: “Chimica Analitica Strumentale”. Edi SES. s.r.l., via M. Pietravalle 5, Napoli.
5) “Clarke’s Analysis of Drugs and Poisons”. Edited by A.C. Moffat, M.D. Osselton, B. Widdop, L.Y. Galichet. The Pharmaceutical Press (Third edition, 2004).
6) European Pharmacopoeia 6a Edition.

Teaching Methods

The teaching consists of theoretical lessons (32 hours) held by the responsible teacher from October to January, and individual practical work in a chemical laboratory (70 hours ), supervised by the same teacher, distributed in two weekly afternoons from October to January.

Contacts/More Information

1) Readiness to offer individual assistance also in English language to incoming students
2) Availability of supporting material and bibliographic references also in english language.
List:The teaching material (lecture notes and required reading) will be made available at the library of the Department (Muroni road, 23).
3) Readiness to accept examination of incoming students also in a foreign language (English)

Other courses

Course year: 1

GENERAL AND INORGANIC CHEMISTRY AND STOICHIOMETRY
14 credits - Base
HUMAN ANATOMY WITH ELEMENTS OF ANIMAL BIOLOGY
9 credits - Base
MATHEMATICS
8 credits - Base
PHYSICS
8 credits - Base
PLANT BIOLOGY
6 credits - Base
PREVENTION AND PROTECTION OF WORKING RISKS IN RESEARCH LABORATORIES AND IN PHARMACIES
4 credits - A scelta dello studente
OTHER TRAINING ACTIVITIES
1 credits - Altro

Course year: 2

ANALYTICAL CHEMISTRY
6 credits - Base
MICROBIOLOGY WITH ELEMENTS OF MEDICAL TERMINOLOGY
10 credits - Base
ORGANIC CHEMISTRY
10 credits - Base
BIOLOGICAL CHEMISTRY
10 credits - Caratterizzante
INORGANIC QUALITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
6 credits - Caratterizzante
PHYSICAL CHEMISTRY
6 credits - Affine/Integrativa
ENGLISH
3 credits - Lingua/Prova Finale

Course year: 3

PHYSIOLOGY
9 credits - Base
APPLIED BIOCHEMISTRY
9 credits - Caratterizzante
CELLULAR PHARMACOLOGY AND TOXICOLOGY
10 credits - Caratterizzante
CHEMICAL ANALYSIS OF FOOD
6 credits - Caratterizzante
QUANTITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
9 credits - Caratterizzante
ADVANCED ORGANIC CHEMISTRY
8 credits - Affine/Integrativa
PHYSICAL METHODS IN ORGANIC CHEMISTRY
7 credits - Affine/Integrativa

Course year: 4

LABORATORY OF DRUGS EXTRACTION AND SYNTHESIS PREPARATION
10 credits - Caratterizzante
ORGANIC QUALITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
9 credits - Caratterizzante
PHARMACEUTICAL CHEMISTRY
10 credits - Caratterizzante
PHARMACOLOGY AND PHARMACOTHERAPY
11 credits - Caratterizzante
TECHNOLOGY, SOCIOECONOMICS AND PHARMACEUTICAL LEGISLATION
12 credits - Caratterizzante
TRAINING
15 credits - Per stages e tirocini

Course year: 5

FINAL TEST
26 credits
ADVANCED PHARMACEUTICAL CHEMISTRY
9 credits - Caratterizzante
APPLIED PHARMACEUTICAL CHEMISTRY
8 credits - Caratterizzante
PHARMACEUTICAL INDUSTRIAL PLANTS
6 credits - Caratterizzante
PHARMACOGNOSY
6 credits - Caratterizzante
TRAINING
15 credits - Per stages e tirocini

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QUANTITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS