Lab-based course on synthetic preparation of drugs and extraction procedures.
THEORETICAL LESSONS
General aspects of the research and development of natural and synthetic biologically active compounds. Rational drug design: SBBD and LBDD.
Retrosynthetic analysis. Multistep synthesis and multicomponent reactions.
Bibliographic search.
Synthetic laboratory techniques: elaboration of a synthetic plan; assembling, conducting and monitoring reactions; work-up of reaction mixtures; isolation, purification and identification of reaction products.
Extraction techniques.
Guidelines for keeping a Laboratory Record and writing laboratory reports.
LABORATORY PRACTICE
General instructions for safe working in chemical laboratories.
Synthesis and extraction of compounds of pharmaceutical interest: isolation, purification and full characterization.
Case-studies: design and synthesis of biologically active compounds.
Separation of compounds in mixture by extration procedures.
