ADVANCED PHARMACEUTICAL CHEMISTRY

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2014/2015

Type of Course:

Characterising

Optional/Mandatory:

Compulsory

Degree:

5-year Single Cycle Master's Degree Programme in PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY

Disciplinary Sector:

Pharmaceutical Chemistry

Language:

Italian

Credits:

Programme Year:

Hours of classroom activity:

Prerequisites:

The student must have solid knowledge of organic chemistry, biochemistry and pharmacology and must have passed the examination of Pharmaceutical and Toxicological Chemistry 1 (for Pharmacy) or Advanced chemistry (for CTF)

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PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY II

PHARMACY

AF code:

40000849

Assessment Methods

Verification of learning:

Final oral exam

Teaching period

First semester

Objectives

The course aims to provide to the students the fundamental knowledge concerning to the structure-activity relationships, mechanism of action, chemical-toxicological and synthesis of marketed drugs. To this end will be analysed the chemical-physical and stereo-electronic properties of drugs in relation to the therapeutic use and will be discussed the synthesis and their metabolism.
It is expected that the students acquire the basic knowledge for the chemical-structural study of the main classes of drugs and the capacity to discuss their mechanisms of action and structure-activity relationships.

Contents

- Drugs of the ANS: parasympathomimetics, parasympatholytic, sympathomimetic, sympatholytic.
- Drugs CNS: sedative-hypnotics, anticonvulsants, skeletal muscle relaxing, anti-Parkinson, antipsychotics, anxiolytics, antidepressants, hallucinogen-stimulants.
- Drugs used in the treatment of pain: NSAIDs, local anesthetics, general anesthetics, opioids, antigout.
- Cardiovascular and Renal Drugs: antihypertensives, vasodilators and antianginals, cardiotonics, antiarrhythmic agents, diuretics.
- Drugs for pulmonary diseases.
- Antihistaminic drugs.
- Antiulcer drugs

Recommended Bibliography

- “Chimica Farmaceutica”, I Ed., Gasco, Gualtieri, Melchiorre. Casa Editrice Ambrosiana (ISBN: 978-88-08-18712-3)
-“Foye’s Principles of Medicinal Chemistry”, VII Ed., Thomas L. Lemke, David A. Williams. Lippincott Williams & Wilkins (ISBN: 978-1-4511-7572-1)
- “Pharmaceutical Substances”. IV Ed. Axel Kleeman, Jurgen Engel. Thieme (ISBN: 1-5889-0031-2)
- “Strategic Applications of Named Reactions in Organic Synthesis”. László Kürti, Barbara Czakó. Elsevier Academic Press (ISBN: 0-12-429785-4)
- “Goodman & Gilman’s. The Pharmacological Basis of Therapeutics” XII Ed., Brunton, Chabner, Knollman, McGraw Hill (ISBN: 978-0-07-162442-8)

Methods of Provision

Conventional

Teaching Methods

During the lectures will be used Power Point presentation, blackboard and molecular models. The slides will be available the day before the lesson on the e-learning platform of the Department. For access to educational materials, interested students will be given the password.

Contacts/More Information

1) Availability from Monday to Friday for clarifications and explanations regarding the teaching, by appointment by phone or by e-mail
2) Readiness to offer individual assistance also in English language to incoming students
3) Availability of supporting material and bibliographic references also in english and french language. List:Lemke, Williams, Foye’s Principles of Medicinal Chemistry, 7th Ed., Lippincott Williams & Wilkins.
- Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins
- Kleemann, Engel, Kutscher, Reichert, Pharmaceutical Substances, 5th Ed., Thieme Verlag.
- Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th Ed., McGraw-Hill Medical Publishing Division.
- Claiden, Greeves, Warren, Organic Chemistry, 2nd Ed., Oxford University Press
4) Readiness to accept examination of incoming students also in a foreign language (English)

Other courses

Course year: 1

GENERAL AND INORGANIC CHEMISTRY AND STOICHIOMETRY
14 credits - Base
HUMAN ANATOMY WITH ELEMENTS OF ANIMAL BIOLOGY
9 credits - Base
MATHEMATICS
8 credits - Base
PHYSICS
8 credits - Base
PLANT BIOLOGY
6 credits - Base
PREVENTION AND PROTECTION OF WORKING RISKS IN RESEARCH LABORATORIES AND IN PHARMACIES
4 credits - A scelta dello studente
OTHER TRAINING ACTIVITIES
1 credits - Altro

Course year: 2

ANALYTICAL CHEMISTRY
6 credits - Base
MICROBIOLOGY WITH ELEMENTS OF MEDICAL TERMINOLOGY
10 credits - Base
ORGANIC CHEMISTRY
10 credits - Base
BIOLOGICAL CHEMISTRY
10 credits - Caratterizzante
INORGANIC QUALITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
6 credits - Caratterizzante
PHYSICAL CHEMISTRY
6 credits - Affine/Integrativa
ENGLISH
3 credits - Lingua/Prova Finale

Course year: 3

PHYSIOLOGY
9 credits - Base
APPLIED BIOCHEMISTRY
9 credits - Caratterizzante
CELLULAR PHARMACOLOGY AND TOXICOLOGY
10 credits - Caratterizzante
CHEMICAL ANALYSIS OF FOOD
6 credits - Caratterizzante
QUANTITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
9 credits - Caratterizzante
ADVANCED ORGANIC CHEMISTRY
8 credits - Affine/Integrativa
PHYSICAL METHODS IN ORGANIC CHEMISTRY
7 credits - Affine/Integrativa

Course year: 4

LABORATORY OF DRUGS EXTRACTION AND SYNTHESIS PREPARATION
10 credits - Caratterizzante
ORGANIC QUALITATIVE PHARMACEUTICAL CHEMICAL ANALYSIS
9 credits - Caratterizzante
PHARMACEUTICAL CHEMISTRY
10 credits - Caratterizzante
PHARMACOLOGY AND PHARMACOTHERAPY
11 credits - Caratterizzante
TECHNOLOGY, SOCIOECONOMICS AND PHARMACEUTICAL LEGISLATION
12 credits - Caratterizzante
TRAINING
15 credits - Per stages e tirocini

Course year: 5

FINAL TEST
26 credits
ADVANCED PHARMACEUTICAL CHEMISTRY
9 credits - Caratterizzante
APPLIED PHARMACEUTICAL CHEMISTRY
8 credits - Caratterizzante
PHARMACEUTICAL INDUSTRIAL PLANTS
6 credits - Caratterizzante
PHARMACOGNOSY
6 credits - Caratterizzante
TRAINING
15 credits - Per stages e tirocini

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ADVANCED PHARMACEUTICAL CHEMISTRY