PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY II

Single discipline educational activity

Course Sheet

Academic Year of enrolment:

2015/2016

Type of Course:

Characterising

Optional/Mandatory:

Compulsory

Degree:

5-year Single Cycle Master's Degree Programme in PHARMACY

Disciplinary Sector:

Pharmaceutical Chemistry

Language:

Italian

Credits:

Programme Year:

Professor and Collaborators:

MURINEDDU Gabriele

Hours of classroom activity:

Prerequisites:

The student must have solid knowledge of organic chemistry, biochemistry and pharmacology and must have passed the examination of Pharmaceutical and Toxicological Chemistry 1

AF code:

40000851

Assessment Methods

Verification of learning:

Final oral exam

Teaching period

First semester

Objectives

The course aims to provide to the students the fundamental knowledge concerning to the structure-activity relationships, mechanism of action, chemical-toxicological and synthesis of marketed drugs. To this end will be analysed the chemical-physical and stereo-electronic properties of drugs in relation to the therapeutic use and will be discussed the synthesis and their metabolism.
It is expected that the students acquire the basic knowledge for the chemical-structural study of the main classes of drugs and the capacity to discuss their mechanisms of action and structure-activity relationships.

Contents

- Drugs of the ANS: parasympathomimetics, parasympatholytic, sympathomimetic, sympatholytic.
- Drugs CNS: sedative-hypnotics, anticonvulsants, skeletal muscle relaxing, anti-Parkinson, antipsychotics, anxiolytics, antidepressants, hallucinogen-stimulants.
- Drugs used in the treatment of pain: NSAIDs, local anesthetics, general anesthetics, opioids, antigout.
- Cardiovascular and Renal Drugs: antihypertensives, vasodilators and antianginals, cardiotonics, antiarrhythmic agents, diuretics.
- Drugs for pulmonary diseases.
- Antihistaminic drugs.
- Antiulcer drugs

Recommended Bibliography

- “Chimica Farmaceutica”, I Ed., Gasco, Gualtieri, Melchiorre. Casa Editrice Ambrosiana (ISBN: 978-88-08-18712-3)
-“Foye’s Principles of Medicinal Chemistry”, VII Ed., Thomas L. Lemke, David A. Williams. Lippincott Williams & Wilkins (ISBN: 978-1-4511-7572-1)
- “Pharmaceutical Substances”. IV Ed. Axel Kleeman, Jurgen Engel. Thieme (ISBN: 1-5889-0031-2)
- “Strategic Applications of Named Reactions in Organic Synthesis”. László Kürti, Barbara Czakó. Elsevier Academic Press (ISBN: 0-12-429785-4)
- “Goodman & Gilman’s. The Pharmacological Basis of Therapeutics” XII Ed., Brunton, Chabner, Knollman, McGraw Hill (ISBN: 978-0-07-162442-8)

Methods of Provision

Conventional

Teaching Methods

During the lectures will be used Power Point presentation, blackboard and molecular models. The slides will be available the day before the lesson on the e-learning platform of the Department. For access to educational materials, interested students will be given the password.

Contacts/More Information

Course attendance is mandatory, a 25% of absences are allowed (presences will be taken with the signature)

1) Availability from Monday to Friday for clarifications and explanations regarding the teaching, by appointment by phone or by e-mail
2) Readiness to offer individual assistance also in English language to incoming students
3) Availability of supporting material and bibliographic references also in english and french language. List:Lemke, Williams, Foyes Principles of Medicinal Chemistry, 7th Ed., Lippincott Williams & Wilkins.
- Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins
- Kleemann, Engel, Kutscher, Reichert, Pharmaceutical Substances, 5th Ed., Thieme Verlag.
- Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th Ed., McGraw-Hill Medical Publishing Division.
- Claiden, Greeves, Warren, Organic Chemistry, 2nd Ed., Oxford University Press
4) Readiness to accept examination of incoming students also in a foreign language (English)

PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY II

Course year: 1

Course year: 2

Course year: 3

Course year: 4

Course year: 5

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PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY II